Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012.
Identifieur interne : 000311 ( Main/Exploration ); précédent : 000310; suivant : 000312Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012.
Auteurs : A. Meijer [Pays-Bas] ; M. Jonges ; P. Van Beek ; C M Swaan ; A D Osterhaus ; R S Daniels ; A C Hurt ; M P KoopmansSource :
- Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin [ 1560-7917 ] ; 2012.
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Antiviraux (pharmacologie), Données de séquences moléculaires (MeSH), Espagne (MeSH), Grippe humaine (diagnostic), Grippe humaine (traitement médicamenteux), Grippe humaine (virologie), Humains (MeSH), Jeune adulte (MeSH), Mutation (MeSH), Oséltamivir (pharmacologie), Pays-Bas (MeSH), Résistance virale aux médicaments (génétique), Résultat thérapeutique (MeSH), Sialidase (génétique), Sous-type H1N1 du virus de la grippe A (effets des médicaments et des substances chimiques), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), Surveillance sentinelle (MeSH), Voyage (MeSH).
- MESH :
- diagnostic : Grippe humaine.
- effets des médicaments et des substances chimiques : Sous-type H1N1 du virus de la grippe A.
- génétique : Résistance virale aux médicaments, Sialidase, Sous-type H1N1 du virus de la grippe A.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- pharmacologie : Antiviraux, Oséltamivir.
- traitement médicamenteux : Grippe humaine.
- virologie : Grippe humaine.
- Adolescent, Données de séquences moléculaires, Espagne, Humains, Jeune adulte, Mutation, Pays-Bas, Résultat thérapeutique, Surveillance sentinelle, Voyage.
- Wicri :
English descriptors
- KwdEn :
- Adolescent (MeSH), Antiviral Agents (pharmacology), Drug Resistance, Viral (genetics), Humans (MeSH), Influenza A Virus, H1N1 Subtype (drug effects), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (diagnosis), Influenza, Human (drug therapy), Influenza, Human (virology), Molecular Sequence Data (MeSH), Mutation (MeSH), Netherlands (MeSH), Neuraminidase (genetics), Oseltamivir (pharmacology), Sentinel Surveillance (MeSH), Spain (MeSH), Travel (MeSH), Treatment Outcome (MeSH), Young Adult (MeSH).
- MESH :
- chemical , genetics : Neuraminidase.
- chemical , pharmacology : Antiviral Agents, Oseltamivir.
- geographic : Netherlands, Spain.
- diagnosis : Influenza, Human.
- drug effects : Influenza A Virus, H1N1 Subtype.
- drug therapy : Influenza, Human.
- genetics : Drug Resistance, Viral, Influenza A Virus, H1N1 Subtype.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adolescent, Humans, Molecular Sequence Data, Mutation, Sentinel Surveillance, Travel, Treatment Outcome, Young Adult.
Abstract
Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.
PubMed: 22971326
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012.</title><author><name sortKey="Meijer, A" sort="Meijer, A" uniqKey="Meijer A" first="A" last="Meijer">A. Meijer</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. adam.meijer@rivm.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Jonges, M" sort="Jonges, M" uniqKey="Jonges M" first="M" last="Jonges">M. Jonges</name></author><author><name sortKey="Van Beek, P" sort="Van Beek, P" uniqKey="Van Beek P" first="P" last="Van Beek">P. Van Beek</name></author><author><name sortKey="Swaan, C M" sort="Swaan, C M" uniqKey="Swaan C" first="C M" last="Swaan">C M Swaan</name></author><author><name sortKey="Osterhaus, A D" sort="Osterhaus, A D" uniqKey="Osterhaus A" first="A D" last="Osterhaus">A D Osterhaus</name></author><author><name sortKey="Daniels, R S" sort="Daniels, R S" uniqKey="Daniels R" first="R S" last="Daniels">R S Daniels</name></author><author><name sortKey="Hurt, A C" sort="Hurt, A C" uniqKey="Hurt A" first="A C" last="Hurt">A C Hurt</name></author><author><name sortKey="Koopmans, M P" sort="Koopmans, M P" uniqKey="Koopmans M" first="M P" last="Koopmans">M P Koopmans</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22971326</idno><idno type="pmid">22971326</idno><idno type="wicri:Area/Main/Corpus">00282</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">00282</idno><idno type="wicri:Area/Main/Curation">000282</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000282</idno><idno type="wicri:Area/Main/Exploration">000282</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012.</title><author><name sortKey="Meijer, A" sort="Meijer, A" uniqKey="Meijer A" first="A" last="Meijer">A. Meijer</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. adam.meijer@rivm.nl</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven</wicri:regionArea><wicri:noRegion>Bilthoven</wicri:noRegion></affiliation></author><author><name sortKey="Jonges, M" sort="Jonges, M" uniqKey="Jonges M" first="M" last="Jonges">M. Jonges</name></author><author><name sortKey="Van Beek, P" sort="Van Beek, P" uniqKey="Van Beek P" first="P" last="Van Beek">P. Van Beek</name></author><author><name sortKey="Swaan, C M" sort="Swaan, C M" uniqKey="Swaan C" first="C M" last="Swaan">C M Swaan</name></author><author><name sortKey="Osterhaus, A D" sort="Osterhaus, A D" uniqKey="Osterhaus A" first="A D" last="Osterhaus">A D Osterhaus</name></author><author><name sortKey="Daniels, R S" sort="Daniels, R S" uniqKey="Daniels R" first="R S" last="Daniels">R S Daniels</name></author><author><name sortKey="Hurt, A C" sort="Hurt, A C" uniqKey="Hurt A" first="A C" last="Hurt">A C Hurt</name></author><author><name sortKey="Koopmans, M P" sort="Koopmans, M P" uniqKey="Koopmans M" first="M P" last="Koopmans">M P Koopmans</name></author></analytic><series><title level="j">Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</title><idno type="eISSN">1560-7917</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Antiviral Agents (pharmacology)</term><term>Drug Resistance, Viral (genetics)</term><term>Humans (MeSH)</term><term>Influenza A Virus, H1N1 Subtype (drug effects)</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (isolation & purification)</term><term>Influenza, Human (diagnosis)</term><term>Influenza, Human (drug therapy)</term><term>Influenza, Human (virology)</term><term>Molecular Sequence Data (MeSH)</term><term>Mutation (MeSH)</term><term>Netherlands (MeSH)</term><term>Neuraminidase (genetics)</term><term>Oseltamivir (pharmacology)</term><term>Sentinel Surveillance (MeSH)</term><term>Spain (MeSH)</term><term>Travel (MeSH)</term><term>Treatment Outcome (MeSH)</term><term>Young Adult (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Antiviraux (pharmacologie)</term><term>Données de séquences moléculaires (MeSH)</term><term>Espagne (MeSH)</term><term>Grippe humaine (diagnostic)</term><term>Grippe humaine (traitement médicamenteux)</term><term>Grippe humaine (virologie)</term><term>Humains (MeSH)</term><term>Jeune adulte (MeSH)</term><term>Mutation (MeSH)</term><term>Oséltamivir (pharmacologie)</term><term>Pays-Bas (MeSH)</term><term>Résistance virale aux médicaments (génétique)</term><term>Résultat thérapeutique (MeSH)</term><term>Sialidase (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (effets des médicaments et des substances chimiques)</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term><term>Surveillance sentinelle (MeSH)</term><term>Voyage (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Neuraminidase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Netherlands</term><term>Spain</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Drug Resistance, Viral</term><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Résistance virale aux médicaments</term><term>Sialidase</term><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiviraux</term><term>Oséltamivir</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Humans</term><term>Molecular Sequence Data</term><term>Mutation</term><term>Sentinel Surveillance</term><term>Travel</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Données de séquences moléculaires</term><term>Espagne</term><term>Humains</term><term>Jeune adulte</term><term>Mutation</term><term>Pays-Bas</term><term>Résultat thérapeutique</term><term>Surveillance sentinelle</term><term>Voyage</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Pays-Bas</term><term>Espagne</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22971326</PMID><DateCompleted><Year>2012</Year><Month>11</Month><Day>16</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>22</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1560-7917</ISSN><JournalIssue CitedMedium="Internet"><Volume>17</Volume><Issue>36</Issue><PubDate><Year>2012</Year><Month>Sep</Month><Day>06</Day></PubDate></JournalIssue><Title>Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin</Title><ISOAbbreviation>Euro Surveill.</ISOAbbreviation></Journal><ArticleTitle>Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012.</ArticleTitle><Pagination><MedlinePgn>20266</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">20266</ELocationID><Abstract><AbstractText>Two Dutch travellers were infected with oseltamivir-resistant influenza A(H1N1)pdm09 viruses with an H275Y neuraminidase substitution in early August 2012. Both cases were probably infected during separate holidays at the Catalonian coast (Spain). No epidemiological connection between the two cases was found, and neither of them was treated with oseltamivir before specimen collection. Genetic analysis of the neuraminidase gene revealed the presence of previously described permissive mutations that may increase the likelihood of such strains emerging and spreading widely.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Meijer</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratory for Infectious Diseases and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands. adam.meijer@rivm.nl</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jonges</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>van Beek</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Swaan</LastName><ForeName>C M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Osterhaus</LastName><ForeName>A D</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Daniels</LastName><ForeName>R S</ForeName><Initials>RS</Initials></Author><Author ValidYN="Y"><LastName>Hurt</LastName><ForeName>A C</ForeName><Initials>AC</Initials></Author><Author ValidYN="Y"><LastName>Koopmans</LastName><ForeName>M P</ForeName><Initials>MP</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>MC_U117512723</GrantID><Agency>Medical Research Council</Agency><Country>United Kingdom</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2012</Year><Month>09</Month><Day>06</Day></ArticleDate></Article><MedlineJournalInfo><Country>Sweden</Country><MedlineTA>Euro Surveill</MedlineTA><NlmUniqueID>100887452</NlmUniqueID><ISSNLinking>1025-496X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber><NameOfSubstance UI="D009439">Neuraminidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024882" MajorTopicYN="N">Drug Resistance, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009154" MajorTopicYN="N">Mutation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009426" MajorTopicYN="N" Type="Geographic">Netherlands</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009439" MajorTopicYN="N">Neuraminidase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018571" MajorTopicYN="N">Sentinel Surveillance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014195" MajorTopicYN="Y">Travel</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>9</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>9</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>12</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22971326</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Pays-Bas</li></country></list><tree><noCountry><name sortKey="Daniels, R S" sort="Daniels, R S" uniqKey="Daniels R" first="R S" last="Daniels">R S Daniels</name><name sortKey="Hurt, A C" sort="Hurt, A C" uniqKey="Hurt A" first="A C" last="Hurt">A C Hurt</name><name sortKey="Jonges, M" sort="Jonges, M" uniqKey="Jonges M" first="M" last="Jonges">M. Jonges</name><name sortKey="Koopmans, M P" sort="Koopmans, M P" uniqKey="Koopmans M" first="M P" last="Koopmans">M P Koopmans</name><name sortKey="Osterhaus, A D" sort="Osterhaus, A D" uniqKey="Osterhaus A" first="A D" last="Osterhaus">A D Osterhaus</name><name sortKey="Swaan, C M" sort="Swaan, C M" uniqKey="Swaan C" first="C M" last="Swaan">C M Swaan</name><name sortKey="Van Beek, P" sort="Van Beek, P" uniqKey="Van Beek P" first="P" last="Van Beek">P. Van Beek</name></noCountry><country name="Pays-Bas"><noRegion><name sortKey="Meijer, A" sort="Meijer, A" uniqKey="Meijer A" first="A" last="Meijer">A. Meijer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/GrippeEspagneV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000311 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000311 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= GrippeEspagneV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:22971326
|texte= Oseltamivir-resistant influenza A(H1N1)pdm09 virus in Dutch travellers returning from Spain, August 2012.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22971326" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a GrippeEspagneV1
| This area was generated with Dilib version V0.6.37. |  |